Th17 Lymphocytes

Dooku representing a Th17 cell Dooku, in his original role as a Jedi, represents a Th17 cell. However, when Dooku becomes power hungry, he crosses to the dark side, attacking the Jedi Order he once served.

Th17 cells are a subset of CD4+ T-lymphocytes with a pro-inflammatory bias. Th17 cells play a key role in the defence against extracellular bacteria and fungal infections as well as maintaining mucosal barrier defences.

Dysregulation of Th17 cells has been associated with inflammatory conditions and autoimmune disorders, where the body attacks its own cells, such as in rheumatoid arthritis. The Th17 population can also become depleted during HIV infection and leaves sufferers prone to recurrent infections.



Soluble Mediators